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5,6-Methylenedioxy-2-aminoindane is a drug developed in the 1990s by a team led by David E. Nichols at Purdue University. It acts as a non-neurotoxic and highly sel ective serotonin releasing agent in vitro and produces entactogen effects in humans.

Chemically, MDAI is very similar to 3,4-methylenedioxyamphetamine (MDA), which is principally used as a recreational drug, the main difference being the existence of a bond between the alpha-methyl group of the alkylamino amphetamine side chain and the benzene nucleus (Indane ring).

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